Research & journal articles

Translating research from the laboratory into clinical practice

Our specialist pathologists are regularly involved in research projects, both with colleagues and external organisations, and also contribute to medical journals and publications.

Recent research contributions

Below is a list of articles produced by DHM pathologists and scientific staff.

Wehrhahn M, Robson J, Brown S, Bursle E, Byrne S, New D,  Chong S, Newcombe J, Siversten T, Hadlow N.Self-collection: An appropriate alternative during the SARS-CoV-2 pandemicJ Clin Virol. 2020; 128:1044172020
Venning V, Myint E, Pyne J, Clark S.

Poorly differentiated cutaneous squamous cell carcinoma with osteoclast-like giant cell: A rare, aggressive variant. Clin Case Rep. 2019; 7(2):340–342


Pyne J, Myint E, Clark S, Barr E, Hou R.

Early invasive squamous cell carcinoma recurrence rates: A study examining surgical margins, tumor surface diameter, invasion depth, and grade of differentiation in 1,296 cases over 9 years. J Cutan Pathol. 2019; 46(2):111–116


Rizk M, Alian M, Tschandl P, Gorji M, Hishon M, Clark S, et al. 

A prospective diagnostic study on povidone-iodine retention in lesions suspected to be squamous cell carcinoma or keratoacanthoma. Australas J Dermatol. 2019; 60(1):e33–39


Fomiatti J, Clark S, Rosendahl C.Dermatoscopic chaos of border-abruptness led to diagnosis of a minute melanoma. Australas J Dermatol. 2019; 60(1):e62–64


Pyne J, Myint E, Clark S, Clifopoulos C, Fishburn P, Gorji M, Hou R.Squamous cell carcinoma: Pain as a clue to increased tumour diameter, increased invasion depth, the grade of differentiation, acantholysis and perineural invasion. Clin Exp Dermatol. 2020; 45(2):180–186


Sebaratnam D, Wong X, Kim, L, Cheung K.

Alopecia following Deoxycholic acid treatment for submental adiposity. JAMA Facial Plast Surg. 2019; 21(6):571–572


Yang A, Cheung K, Kossard S, Murrell D.

Atypical disseminated variant of Galli-Galli Disease: A review of the literature. Am J  Dermatopathol. 2019


Venning V, Choi-Lombardi S, Wong X, Cheung K, Sebaratnam D.

A comparison of physical modalities in Galli-Galli disease. Australas J Dermatol. 2019; 60(4):320–322


Yang A, Cordoba C, Cheung K, Konya J.

Merkel cell carcinoma in situ: new insights into the cells of the origin. Australas J Dermatol. 2019; 60(4):e311–313

Habibalahi A, Bala C, Allende A, Anwer A, Goldys E.

Novel automated non invasive detection of ocular surface squamous neoplasia using multispectral autofluorescence imaging. Ocul Surf. 2019; 17(3):540–550

Habibalahi A, Allende A, Bala C, Anwer A, Mukhopadhyay S, Goldys E.Optimized Autofluorescence Spectral Signature for Non-Invasive Diagnostics of Ocular
Surface Squamous Neoplasia (OSSN)
 IEEE Access. 2019; 7:141343–141351
Go J, Mandujano-Sanchez J, Vickers a, Sadaka A, Ortiz J, Berry S, Yalamanchili S, Lee A.Primary central nervous system lymphoma of the optic chiasm. Can J Ophthalmol. 2019; 54(3):e134–1402019
Vythianathan M, Fox P, Rhodes G, Armes J.Primary squamous carcinoma of breast – a rare entity: report of two cases and review of the literature. Pathology. 2019; 51(5):529–5312019
Pathmanathan N, et al.  Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications. J Pathol. 2019; 247(2):214–2272019
Janssen A, Donnelly C, Elder E, Pathmanathan N, Shaw T. Factors Influencing Implementation of an Electronic Medical Record in a Tertiary Cancer Centre. Stud Health Technol Inform. 2019; 266:95–1002019
Soper J, Bonar F, O’Sullivan D, McCredie J, Willert H.Thalidomide and neurotrophism. Skeletal Radiol. 2019; 48(4):517–5252019
Hui M, Merani R, Bonar F, Hong A, Fung A.Presumed choroidal metastasis from soft tissue myoepithelial carcinoma. Am J Ophthalmol Case Rep. 2019; 14:55–572019
Vargas A, Maclean F, Bonar F, Mahar A, Gill A.NR4A3 immunohistochemistry lacks sensitivity for the diagnosis of extraskeletal myxoid chondrosarcoma. Am J Surg Pathol. 2019; 43(12):1726–17282019
Cheah A, Zou Y, Lanigan C, Billings S, Rubin B, Hornick J, Goldblum J.ALK expression in angiomatoid fibrous histiocytoma: a potential diagnostic pitfall. Am J Surg Pathol. 2019; 43(1):93–1012019
Al-Ibraheemi A, Broehm C, Tanas M, Horvai A, Rubin B, Cheah A, et al.Desmoplastic small round cell tumors with atypical presentations: a report of 34 cases. Int J Surg Pathol. 2019; 27(3):236–2432019
Vargas A, Selinger C, Satgunaseelan L, Cooper W, Gupta R, Stalley P, Brown W, Soper J, Schatz J, Boyle R, Thomas D, Tattersall M, Bhadri V, Maclean F, Bonar F, et al.FISH analysis of selected soft tissue tumors: Diagnostic experience in a tertiary center. Asia Pac J Clin Oncol. 2019; 15(1):38–472019
Othman J, Bonar F, Brown W, Boyle R, Khoo T.Multiply relapsed mixed histiocytosis in an adult responding to clofarabine after failure of cladribine. Leuk Lymphoma. 2020; 61(2):477–4802020
Turchini J, Gill A.Morphologic clues to succinate dehydrogenase (SDH) deficiency in pheochromocytomas and paragangliomas. Am J Surg Pathol. 2020; 44(3):422–4242020
Nahm C, Turchini J, Jamieson N, Moon E, Sioson L, et al.Biomarker panel predicts survival after resection in pancreatic ductal adenocarcinoma: a multi-institutional cohort study. Eur J Surg Oncol. 2019; 45(2):218–2242019
Rutagengwa D, Rathore P, Morris E.Ovarian‐type epithelial tumour of borderline malignancy: a rare testicular tumour in Australia. ANZ J Surg. 2019; 89(12):1676–16772019
Maghsoudi A, Roberts J, Russell P.Uterine intravascular adenomyomatosis: a bizarre hybrid lesion? Pathology. 2019; 51(1):120–1222019
Machalek D, Roberts J, Garland S, Thurloe J, Richards A, Chambers I, Sivertsen T, Farnsworth A.Routine cervical screening by primary HPV testing: early findings in the renewed National Cervical Screening Program. Med J Aust. 2019; 211(3):133–1192019
Shilling H, Murray G, Brotherton J, Hawkes D, Saville M, Sivertsen T, Chambers I, Roberts J, Farnsworth A, et al. Monitoring human papillomavirus prevalence among young Australian women undergoing routine chlamydia screening. Vaccine. 2020; 38(5):1186–11932020
Cvejic E, Poynten I, Kelly P, Jin F, Howard K, Grulich A, Templeton D, Hillman R, Law C, Roberts J, et al. Psychological and utility-based quality of life impact of screening test results for anal precancerous lesions in gay and bisexual men: baseline findings from the study of the prevention of anal cancer. Sex Transm Infect. 20192019
Rosales B, Langton-Lockton J, Cornall A, Roberts J, Hillman R, Webster A.Transplant recipients and anal neoplasia study: design, methods and participant characteristics of a prevalence study. Transplant Direct. 2019; 5(4):e4342019
Goddard S, Poynten I, Petoumenos K, Jin F, Hillman R, Law C, Roberts J, et al.Prevalence, incidence and predictors of anal Chlamydia trachomatis, anal Neisseria gonorrhoeae and syphilis among older gay and bisexual men in the longitudinal study for the prevention of anal cancer (SPANC). Sex Transm Infect. 2019; 95(7):477–4832019
Goddard S, Templeton D, Petoumenos K, Jin F, Hillman R, Law C, Roberts J, et al.Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men: baseline data from the study of the prevention of anal cancer (SPANC). Cancer Epidemiol. 2019; 58:12-162019
Delprado W, et al.An analysis of a multiple biomarker panel to better predict prostate cancer metastasis after radical prostatectomy. Int J Cancer. 2019; 144(5):1151–11592019
Blazevski A, Scheltema MJ, Yuen B, Masand N, Nguyen TV, Delprado W, et al. Oncological and quality-of-life outcomes following focal irreversible electroporation as primary treatment for localised prostate cancer: a biopsy-monitored prospective cohort. Eur Urol Oncol. 20192019
Scheltema M, Chang J, Stricker P, van Leeuwen P, Nguyen Q, Ho B, Delprado W, et al. Diagnostic accuracy of 68Ga-prostate-specific membrane antigen (PSMA) positron-emission tomography (PET) and multiparametric (mp)MRI to detect intermediate-grade intra-prostatic prostate cancer using whole-mount pathology: impact of the addition of 68Ga-PSMA PET to mpMRI. BJU Int. 2019; 124 Suppl 1:42–492019
Quinn D, Stricker P, Kench J, Grogan J, Haynes A, Henshall S, Grygiel J, Delprado W, Turner J, et al.p53 nuclear accumulation as an early indicator of lethal prostate cancer. Br J Cancer. 2019; 121(7):578–5832019
Macneil J, Maclean F, Delprado W.Pathological characteristics of prostate cancer occurring in younger men: a retrospective study of prostatectomy patients. Urology. 2019; 134:163–1672019
Delprado W, et al.The MRI in active surveillance "MRIAS" trial: use of baseline mpMRI and saturation biopsy to reduce the frequency of surveillance prostate biopsies. J Urol. 20192019
Rutagengwa D, Rathore P, Morris E.Ovarian‐type epithelial tumour of borderline malignancy: a rare testicular tumour in Australia. ANZ J Surg. 2019; 89(12): 1676–1677 2019
Al-Hakeem Y, Raz O, Gacs Z, Maclean F, Varol C.Magnetic resonance image-guided focal laser ablation in clinically localized prostate cancer: safety and efficacy. ANZ J Surg. 2019; 89(12):1610–16142019
Watts M, Kim R, Ahuja V, Robertson G, Sultana Y, Wehrhahn M, et al. Comparison of loop-mediated isothermal amplification and real-time PCR assays for detection of Strongyloides larvae in different specimen matrices. J Clin Microbiol. 2019; 57(4):e01173–182019
Wehrhahn M, Keighley K, Kurtovic J, et al.A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain. Anaerobe. 2019; 55:117–1232019



Pyne J, Myint E, Barr E, Clark S, Hou R.

Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases. Dermatol Pract Concept. 2018; 8(4):314–319


Pyne J, Barr E, Myint E, Clark S, David M, Na R.

Invasive squamous cell carcinoma: comparison of differentiation grade and tumour depth by anatomical site in 1666 tumours. Clin Exp Dermatol. 2018; 43(1):3–10


 Wuesthoff C, Allende A, Patel N.IgG4 disease of the ear: Report and review. SAGE Open Med Case Rep. 2018; 6:2050313X18791428


Sadaka A, Ortiz J, Berry S, Lee AG, Li HK, Divatia M, Malik A.Late proptosis and ophthalmoplegia from hydrogel scleral buckle. Can J Ophthalmol. 2018; 53(5):e190–193


Chang E, Shah R, Smith S, Sadaka A, Ortiz Gomez J, Chevez-Barrios P, Lee A.Neuro-ophthalmic manifestations of pituitary carcinoma. J Neuroophthalmol. 2018; 38(3):339–341


Patel S, Nakawah M, Sadaka A, Berry S, Ortiz Gomez J, Powell S, Lee A.Supraorbital nerve and cavernous sinus invasion with poorly differentiated carcinoma of unknown primary. Neuroophthalmology. 2018; 42(5):312–315


Wang S, Carrington M, Berndt SI, Slager SL et al including Turner J.HLA class I and II diversity contributes to the etiologic heterogeneity of non-Hodgkin lymphoma subtypes. Cancer Res. 2018; 78(14):4086–4096 


Hakemi Y, Pyne J, Muljono A, Myint E.Indolent primary cutaneous CD8 positive T-cell lymphoid proliferations. Pathology. 2018; 50(5):575–578


Raghavendra A, Kalita-de Croft P, Vargas A, Smart C, Simpson P, Saunus J, Lakhani S.Expression of MAGE-A and NY-ESO-1 cancer/testis antigens is enriched in triple-negative invasive breast cancers. Histopathology. 2018; 73(1):68–802018
Johnson J, Bessette D, Saunus J, Smart C, Song S, Johnston R, Cocciardi S, Rozali E, Johnstone C, Vargas A, et al.Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast Cancer Res Treat. 2018; 170(1):179–1882018
Wang X, Mahajan H, Dickinson N, Cox C, Byth K, Bayly A, Cahill M, Pathmanathan N.Fine needle aspiration biopsy cytology of phyllodes tumour and fibroadenoma: A cytomorphological study of 104 cases. Diagn Cytopathol. 2018; 46(11):927–9352018
Van de Pol G, Bonar F, Salmon L, Roe J, Pinczewski L.Supercritical carbon dioxide-sterilized bone allograft in the treatment of tunnel defects in 2-stage revision anterior cruciate ligament reconstruction: a histologic evaluation. Arthroscopy. 2018; 34(3):706–7132018
Narayanappa H, Low T, Vargas Calderon A, Selinger C, Gupta R.Inflammatory myofibroblastic tumours of the head and neck. Pathology. 2018; 50(3):356–3582018
Pan S, O'Donnell J, Lemech LD, Roncolato F, Bonar F.Common femoral artery disease in antiphospholipid syndrome: histopathology. ANZ J Surg. 2018; 88(11):1203–12042018
Turchini J, Cheung V, Tischler A, De Krijger R, Gill A.Pathology and genetics of phaeochromocytoma and paraganglioma. Histopathology. 2018; 72(1):97–1052018
Al-Mansouri L, Poursoltan P, Simons M, Muljono A, Boyages J.Primary breast cancer of the vulva: a case report and literature review. J Obstet Gynaecol Res. 2018; 44(12):2190–21942018
Muronda M, Russell P.Combined ovarian serous cystadenoma and thecoma. Pathology. 2018; 50(3):367–3692018
Ramanayake N, Russell P, Yang V.High grade serous intraepithelial carcinoma arising in a benign serous cyst – a bridge too far? Pathology. 2018; 50(5):485–4892018
Poynten I, Waterboer T, Jin F, Templeton D, Hillman R, Law C, Cornall A, Tabrizi S, Roberts J, et al. Human Papillomavirus seroprevalence and association with anal HPV infection and squamous intraepithelial lesions in Australian gay and bisexual men. Cancer Epidemiol Biomarkers Prev. 2018; 27(7):768–7752018
Williamson S, Rao P, Hes O, Epstein J, Smith S, Picken M, Zhou M, Tretiakova M, Tickoo S, Chen Y, Reuter V, Fleming S, Maclean F, et al.Challenges in pathologic staging of renal cell carcinoma: a study of interobserver variability among urologic pathologists. Am J Surg Pathol. 2018; 42(9):1253–12612018
Berger I, Annabattula C, Lewis J, Shetty D, Kam J, Maclean F, et al.Ga-PSMA PET/CT vs. mpMRI for locoregional prostate cancer staging: correlation with final histopathology. Prostate Cancer Prostatic Dis. 2018; 21(2):204–2112018
Maclean F, et al. Reappraisal of morphologic differences between renal medullary carcinoma, collecting duct carcinoma, and fumarate hydratase-deficient renal cell carcinoma. Am J Surg Pathol. 2018; 42(3):279–2922018
Novis E, Raman A, Maclean F, Lazzaro E. Glomus tumour of the kidney: a case report and review of the literature. ANZ J Surg. 2018; 88(6):653–6542018
Kam J, Yuminaga Y, Maclean F, Louie-Johnsun M.Rapidly growing massive pleomorphic rhabdomyosarcoma of the bladder presenting with bladder outlet obstruction. ANZ J Surg. 2018; 88(3):e208–2092018
Delprado W, et alRadiomic features on MRI enable risk categorization of prostate cancer patients on active surveillance: Preliminary findings. J Magn Reson Imaging. 2018; 48(3):818 – 8282018
Penzias G, Singanamalli A, Elliott R, Gollamudi J, Shih N, Feldman M, Stricker P, Delprado W, et al. Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: preliminary findings. PLoS One. 2018; 13(8):e02007302018
Nag N, Millar J, Davis I, Costello S, Duthie J, Mark S, Delprado W, et al.Development of indicators to assess quality of care for prostate cancer. Eur Urol Focus. 2018; 4(1):57–632018
Gielchinsky I, Chang J, Cusick T, Delprado W, et al.Prostate cancer in 432 men aged <50 years in the prostate-specific antigen era: a new outlook. BJU Int. 2018; 122 Suppl 5:35–412018
Gielchinsky I, Scheltema M, Cusick T, Chang J, Shnier R, Moses D, Delprado W, et al.Reduced sensitivity of multiparametric MRI for clinically significant prostate cancer in men under the age of 50. Res Rep Urol. 2018; 10:145-1502018
Turchini J, Buckland M, Gill A, Battye S. Three-dimensional pathology specimen modeling using "structure-from-motion" photogrammetry: a powerful new tool for surgical pathology. Arch Pathol Lab Med. 2018; 142(11):1415–14202018
Armstrong B, Wehrhahn MLow additional yield from prolonged culture of urine and differential detection of Actinotignum schaalii in a private laboratory setting. Pathology. 2018; 50(7):766–7672018
Fox O, Chong C, Wang S, Wehrhahn M, et al.Anterior chamber culture at the conclusion of cataract surgery and its relation to post-cataract surgery endophthalmitis. The Open Access Journal of Science and Technology. 2018; 5:ID 101283 
Rowe J, Cheah A, Calhoun B.

Lipomatous tumors of the breast: a contemporary review. Semin Diagn Pathol. 2017; 34(5):453–461


Erstine E, Tetzlaff M, Ko J, Prieto V, Cheah A, Billings S.

Living on the edge: diagnosing sarcomatoid melanoma using histopathologic cues at the edge of a dedifferentiated tumor: a report of 2 cases and review of the literature. Am J Dermatopathol. 2017; 39(8):593–598


de Silva S, Copping R, Malouf D, Hutton A, Maclean F, Aslan P.Frequency of angiomyolipomas among echogenic nonshadowing renal masses (> 4 mm) found at ultrasound and the utility of MRI for diagnosis. AJR Am J Roentgenol. 2017; 209(5):1074–1080


Knight D, Giglio S, Huntington R, Wehrhahn M, et al. 

Surveillance for antimicrobial resistance in Australian isolates of Clostridium difficile, 2013–14. J Antimicrob Chemother. 2015; 70(11):2992–2999


Donoghue S, Vekic D, Wehrhahn M, Whitfeld M. 

Staphylococcus lugdunensis: Case report and discussion. Australas J Dermatol. 2014; 55(4):301–303